Interactions
Variants at each interface in 928 assessable complex structures (experimental from the PDB, predicted by AlphaFold-Multimer and RoseTTAFold2-PPI) were compared with variants at nearby solvent-exposed control positions: 1,088 scored interfaces. 353 of 395 protein pairs with a scored structure are interaction partners with functional support: at least one complex with q < 0.05 and |Cohen's d| ≥ 0.2. As in Fig. 6c,d, complexes of the same pair and source whose interfaces overlap (IoU ≥ 0.3) are merged into one point (552 interfaces); corner counts are supported complexes (distinct pairs). Click a point to open its structure.
Pathway activity
Abundance
Interfaces
| Protein | Partner | Source | Activity d | q | Abundance d | q | Interface positions | Supported | |
|---|---|---|---|---|---|---|---|---|---|
| ARAF | CRAF | AF-M | -0.75 | 1.6e-54 | -0.09 | 0.266 | 14 | supported | Structure ↗ |
| ARAF | BRAF | AF-M | -0.77 | 9.6e-50 | -0.25 | 0.005 | 11 | supported | Structure ↗ |
| ARAF | KSR1 | AF-M | -0.83 | 5.8e-49 | +0.02 | 0.444 | 13 | supported | Structure ↗ |
| ARAF | KSR2 | AF-M | -0.70 | 1.6e-47 | +0.05 | 0.103 | 14 | supported | Structure ↗ |
| ARAF | EGFR | RF2-PPI | -0.88 | 3.6e-40 | -0.09 | 0.182 | 9 | supported | Structure ↗ |
| ARAF | SFN | AF-M | +2.21 | 8.1e-24 | +0.34 | 0.110 | 8 | supported | Structure ↗ |
| ARAF | RABGGTB | RF2-PPI | +2.60 | 6.0e-23 | +0.40 | 5.1e-10 | 8 | supported | Structure ↗ |
| ARAF | RRAS | AF-M | +0.02 | 0.477 | +0.62 | 1.0e-21 | 8 | supported | Structure ↗ |
| ARAF | RRAS2 | AF-M | +0.34 | 8.1e-11 | +0.32 | 7.0e-21 | 14 | supported | Structure ↗ |
| ARAF | NRAS | AF-M | +0.34 | 1.6e-09 | +0.33 | 9.9e-20 | 14 | supported | Structure ↗ |
| ARAF | KRAS | AF-M | +0.34 | 2.0e-09 | +0.31 | 1.8e-19 | 14 | supported | Structure ↗ |
| ARAF | MEK2 | RF2-PPI | -0.19 | 1.0e-10 | -0.34 | 3.3e-17 | 17 | supported | Structure ↗ |
| ARAF | HRAS | AF-M | +0.34 | 3.7e-09 | +0.28 | 3.8e-17 | 13 | supported | Structure ↗ |
| ARAF | YWHAG | AF-M | +1.97 | 1.1e-16 | +0.35 | 0.187 | 8 | supported | Structure ↗ |
| ARAF | YWHAZ | RF2-PPI | +2.96 | 2.3e-15 | +0.27 | 0.002 | 5 | supported | Structure ↗ |
| ARAF | MAP2K3 | AF-M | -0.53 | 4.3e-14 | -0.30 | 6.6e-06 | 8 | supported | Structure ↗ |
| ARAF | MAP2K5 | AF-M | -0.46 | 1.2e-13 | -0.32 | 9.4e-08 | 11 | supported | Structure ↗ |
| ARAF | A0A1B0GUL7 | RF2-PPI | -0.30 | 1.5e-08 | -0.29 | 4.7e-12 | 17 | supported | Structure ↗ |
| ARAF | YWHAH | RF2-PPI | +2.60 | 2.8e-10 | +0.12 | 0.444 | 4 | supported | Structure ↗ |
| ARAF | STK11 | AF-M | -0.38 | 1.4e-08 | -0.23 | 8.4e-04 | 12 | supported | Structure ↗ |
| ARAF | YWHAZ | AF-M | +1.36 | 1.9e-08 | +0.15 | 0.644 | 13 | supported | Structure ↗ |
| ARAF | YWHAB | AF-M | +1.23 | 5.4e-08 | +0.18 | 0.360 | 14 | supported | Structure ↗ |
| ARAF | YWHAH | AF-M | +1.35 | 2.9e-07 | +0.12 | 0.780 | 12 | supported | Structure ↗ |
| ARAF | YWHAE | AF-M | +1.31 | 2.9e-07 | +0.17 | 0.625 | 12 | supported | Structure ↗ |
| ARAF | MEK1 | RF2-PPI | -0.38 | 4.2e-07 | -0.16 | 0.009 | 8 | supported | Structure ↗ |
| ARAF | YWHAQ | AF-M | +1.25 | 5.0e-06 | +0.14 | 0.739 | 12 | supported | Structure ↗ |
| ARAF | MEK2 | AF-M | -0.23 | 0.003 | -0.23 | 5.0e-05 | 14 | supported | Structure ↗ |
| ARAF | MEK1 | AF-M | -0.23 | 0.007 | -0.23 | 7.5e-05 | 14 | supported | Structure ↗ |
| BRAF | KSR2 STKc_Raf | RF2-PPI | -0.43 | 2.9e-68 | +0.81 | 5.7e-22 | 12 | supported | Structure ↗ |
| BRAF | BRAF STKc_Raf | PDB | -0.38 | 1.0e-50 | +0.78 | 2.7e-17 | 11 | supported | Structure ↗ |
| BRAF | ARAF | AF-M | -0.43 | 2.1e-49 | +0.82 | 9.3e-20 | 11 | supported | Structure ↗ |
| BRAF | KSR2 | AF-M | -0.40 | 4.1e-48 | +0.51 | 4.6e-11 | 20 | supported | Structure ↗ |
| BRAF | CRAF | AF-M | -0.43 | 2.1e-42 | +0.82 | 7.2e-17 | 10 | supported | Structure ↗ |
| BRAF | ITCH | AF-M | +1.01 | 2.5e-39 | -0.57 | 7.0e-10 | 9 | supported | Structure ↗ |
| BRAF | KSR1 | AF-M | -0.38 | 2.4e-37 | +0.48 | 3.7e-09 | 21 | supported | Structure ↗ |
| BRAF | CDC37 | PDB | -0.25 | 3.1e-37 | -0.61 | 2.9e-06 | 11 | supported | Structure ↗ |
| BRAF | KSR1 | RF2-PPI | -0.36 | 1.6e-36 | +0.45 | 3.7e-09 | 21 | supported | Structure ↗ |
| BRAF | YWHAZ res 241-719 | PDB | +1.12 | 2.7e-29 | -0.61 | 8.1e-16 | 10 | supported | Structure ↗ |
| BRAF | MEK2 | RF2-PPI | +0.26 | 4.4e-26 | +0.03 | 0.609 | 9 | supported | Structure ↗ |
| BRAF | MAP2K3 | AF-M | -0.04 | 3.5e-25 | +0.18 | 0.019 | 9 | supported | Structure ↗ |
| BRAF | MAP2K6 | AF-M | -0.05 | 7.2e-24 | +0.21 | 0.009 | 8 | supported | Structure ↗ |
| BRAF | MEK1 | PDB | +0.06 | 9.4e-23 | +0.06 | 0.033 | 17 | supported | Structure ↗ |
| BRAF | STK11 | AF-M | -0.11 | 3.9e-21 | +0.23 | 0.002 | 11 | supported | Structure ↗ |
| BRAF | STK11 | RF2-PPI | -0.13 | 3.9e-16 | +0.24 | 0.002 | 10 | supported | Structure ↗ |
| BRAF | V9P4T4 | PDB | +1.11 | 1.4e-13 | -0.60 | 5.9e-13 | 11 | supported | Structure ↗ |
| BRAF | RAP1A | AF-M | -0.23 | 6.9e-05 | +0.35 | 1.9e-04 | 8 | supported | Structure ↗ |
| BRAF | KRAS | PDB | -0.29 | 1.9e-04 | +0.35 | 9.7e-04 | 6 | supported | Structure ↗ |
| BRAF | BRAF STKc_Raf #2 | PDB | +0.48 | 0.009 | -0.22 | 2.3e-04 | 15 | supported | Structure ↗ |
| BRAF | RAP1B | AF-M | -0.21 | 0.002 | +0.32 | 0.001 | 7 | supported | Structure ↗ |
| BRAF | MRAS | AF-M | -0.21 | 0.009 | +0.31 | 0.002 | 10 | supported | Structure ↗ |
| BRAF | KSR2 res 49-77 | RF2-PPI | -0.28 | 0.033 | -0.02 | 0.534 | 10 | supported | Structure ↗ |
| BRAF | HRAS | AF-M | +0.49 | 0.046 | -0.15 | 0.167 | 11 | supported | Structure ↗ |
| BRAF | MEK1 | RF2-PPI | -0.04 | 1.9e-25 | +0.10 | 0.182 | 10 | not supported | Structure ↗ |
| BRAF | MEK2 | AF-M | -0.09 | 6.9e-20 | +0.12 | 0.069 | 12 | not supported | Structure ↗ |
| BRAF | MEK1 | AF-M | -0.07 | 9.7e-19 | +0.13 | 0.061 | 10 | not supported | Structure ↗ |
| BRAF | A0A1B0GUL7 | RF2-PPI | -0.08 | 5.6e-16 | +0.12 | 0.158 | 8 | not supported | Structure ↗ |
| BRAF | MAP2K7 | AF-M | -0.04 | 6.7e-15 | +0.15 | 0.116 | 5 | not supported | Structure ↗ |
| BRAF | BRAF STKc_Raf #3 | PDB | -0.15 | 0.002 | -0.01 | 0.795 | 13 | not supported | Structure ↗ |
| BRAF | YWHAZ res 239-735 | PDB | -0.07 | 0.045 | +0.09 | 0.388 | 7 | not supported | Structure ↗ |
| BRAF | NRAS | AF-M | +0.42 | 0.127 | -0.14 | 0.883 | 13 | not supported | Structure ↗ |
| BRAF | HSP90AB1 | PDB | +0.23 | 0.834 | -0.05 | 0.215 | 4 | not supported | Structure ↗ |
| BRAF | KRAS | AF-M | +0.32 | 0.295 | -0.07 | 0.445 | 12 | not supported | Structure ↗ |
| BRAF | YWHAZ STKc_Raf | PDB | -0.21 | 0.320 | -0.16 | 0.340 | 5 | not supported | Structure ↗ |
| EGFR | CTR9 | RF2-PPI | +0.79 | 2.4e-48 | +0.22 | 0.002 | 21 | supported | Structure ↗ |
| EGFR | CHIA | RF2-PPI | +1.12 | 7.6e-33 | +0.10 | 0.541 | 6 | supported | Structure ↗ |
| EGFR | EPS15 | RF2-PPI | -1.23 | 3.4e-31 | +0.49 | 1.9e-09 | 9 | supported | Structure ↗ |
| EGFR | ITGB2 | RF2-PPI | -1.23 | 8.6e-29 | +0.28 | 9.7e-04 | 9 | supported | Structure ↗ |
| EGFR | ERBB2 | AF-M | -0.87 | 1.0e-25 | +0.25 | 2.4e-04 | 16 | supported | Structure ↗ |
| EGFR | JPH1 | RF2-PPI | +0.83 | 6.2e-22 | +0.01 | 0.537 | 7 | supported | Structure ↗ |
| EGFR | NCK1 | RF2-PPI | -1.63 | 7.2e-21 | +0.49 | 2.9e-04 | 3 | supported | Structure ↗ |
| EGFR | PPIB | AF-M | -0.84 | 9.4e-18 | +0.37 | 2.2e-04 | 7 | supported | Structure ↗ |
| EGFR | GATB | RF2-PPI | -0.82 | 9.5e-18 | +0.52 | 4.8e-09 | 6 | supported | Structure ↗ |
| EGFR | ADAMTS9 res 694-1073 | RF2-PPI | +0.54 | 2.4e-17 | +0.25 | 3.9e-04 | 12 | supported | Structure ↗ |
| EGFR | LRIG3 | RF2-PPI | -1.04 | 3.3e-17 | +0.38 | 6.0e-05 | 7 | supported | Structure ↗ |
| EGFR | NOTCH2 PTKc_EGFR #2 | RF2-PPI | -0.72 | 3.6e-17 | -0.05 | 0.969 | 13 | supported | Structure ↗ |
| EGFR | ARAF | RF2-PPI | -1.05 | 1.6e-16 | +0.41 | 1.0e-05 | 7 | supported | Structure ↗ |
| EGFR | SH2B3 | RF2-PPI | -0.59 | 1.8e-07 | -0.77 | 3.7e-16 | 10 | supported | Structure ↗ |
| EGFR | IARS1 | RF2-PPI | +0.62 | 9.7e-16 | +0.17 | 0.092 | 13 | supported | Structure ↗ |
| EGFR | PIK3R4 | RF2-PPI | +0.61 | 1.1e-15 | +0.21 | 0.009 | 11 | supported | Structure ↗ |
| EGFR | LSM11 | RF2-PPI | -1.28 | 1.3e-15 | +1.10 | 2.5e-15 | 3 | supported | Structure ↗ |
| EGFR | BUB3 | RF2-PPI | +0.97 | 1.9e-15 | +0.15 | 0.445 | 4 | supported | Structure ↗ |
| EGFR | SEL1L | RF2-PPI | -0.75 | 5.7e-14 | +0.27 | 0.003 | 10 | supported | Structure ↗ |
| EGFR | EGF PTKc_EGFR | AF-M | -0.74 | 3.4e-12 | +0.14 | 0.153 | 10 | supported | Structure ↗ |
| EGFR | CLP1 | RF2-PPI | +0.46 | 4.3e-12 | +0.27 | 3.2e-04 | 11 | supported | Structure ↗ |
| EGFR | MLST8 | RF2-PPI | +0.77 | 4.8e-12 | -0.05 | 0.467 | 4 | supported | Structure ↗ |
| EGFR | ITGA2B | RF2-PPI | +0.57 | 1.4e-11 | +0.07 | 0.887 | 8 | supported | Structure ↗ |
| EGFR | SOS1 | RF2-PPI | +0.56 | 3.6e-11 | +0.10 | 0.061 | 9 | supported | Structure ↗ |
| EGFR | ERRFI1 | AF-M | -0.57 | 5.9e-11 | +0.19 | 2.2e-04 | 24 | supported | Structure ↗ |
| EGFR | ERBB3 | PDB | -0.22 | 0.001 | +0.30 | 2.0e-10 | 20 | supported | Structure ↗ |
| EGFR | KAT7 | RF2-PPI | +0.54 | 3.4e-10 | +0.23 | 0.004 | 9 | supported | Structure ↗ |
| EGFR | ERRFI1 | PDB | -0.48 | 7.7e-10 | +0.25 | 3.4e-05 | 18 | supported | Structure ↗ |
| EGFR | SGSM2 PTKc_EGFR | AF-M | -0.58 | 2.9e-09 | +0.41 | 9.2e-06 | 9 | supported | Structure ↗ |
| EGFR | PLAA | RF2-PPI | +0.54 | 8.3e-09 | +0.17 | 0.451 | 4 | supported | Structure ↗ |
| EGFR | FERMT1 | RF2-PPI | -0.05 | 0.875 | +0.51 | 2.1e-08 | 6 | supported | Structure ↗ |
| EGFR | CTNND1 | RF2-PPI | +0.52 | 2.4e-08 | +0.14 | 0.290 | 8 | supported | Structure ↗ |
| EGFR | SGSM2 PTKc_EGFR #2 | AF-M | -0.79 | 1.8e-07 | +0.62 | 2.2e-06 | 4 | supported | Structure ↗ |
| EGFR | MYO9A | RF2-PPI | -0.60 | 2.6e-07 | +0.29 | 0.001 | 9 | supported | Structure ↗ |
| EGFR | CBLC | RF2-PPI | +0.28 | 0.044 | +0.50 | 5.2e-07 | 5 | supported | Structure ↗ |
| EGFR | B4GALT1 | RF2-PPI | -0.93 | 5.3e-07 | +0.38 | 0.008 | 3 | supported | Structure ↗ |
| EGFR | CRKL | RF2-PPI | +0.57 | 1.1e-06 | -0.05 | 0.519 | 3 | supported | Structure ↗ |
| EGFR | VAV2 | RF2-PPI | -0.01 | 0.556 | -0.68 | 1.2e-06 | 4 | supported | Structure ↗ |
| EGFR | WDR44 | RF2-PPI | +0.33 | 2.7e-06 | +0.25 | 0.004 | 12 | supported | Structure ↗ |
| EGFR | CTNNB1 | RF2-PPI | +0.51 | 4.4e-06 | +0.41 | 7.1e-04 | 4 | supported | Structure ↗ |
| EGFR | ACOT9 | RF2-PPI | +0.34 | 4.9e-06 | +0.16 | 0.185 | 6 | supported | Structure ↗ |
| EGFR | NOTCH2 PTKc_EGFR #3 | RF2-PPI | -0.23 | 0.033 | +0.54 | 1.5e-05 | 4 | supported | Structure ↗ |
| EGFR | LRIG1 | RF2-PPI | -0.47 | 1.9e-05 | +0.32 | 6.1e-04 | 8 | supported | Structure ↗ |
| EGFR | SOS2 PTKc_EGFR | RF2-PPI | -0.48 | 8.8e-05 | +0.26 | 0.016 | 8 | supported | Structure ↗ |
| EGFR | ERBB3 | AF-M | -0.29 | 1.1e-04 | +0.19 | 1.4e-04 | 19 | supported | Structure ↗ |
| EGFR | EED | RF2-PPI | +0.12 | 0.101 | +0.44 | 5.1e-04 | 3 | supported | Structure ↗ |
| EGFR | MIOS | RF2-PPI | -0.10 | 0.902 | +0.33 | 5.1e-04 | 6 | supported | Structure ↗ |
| EGFR | ANKRD13A | RF2-PPI | +0.25 | 7.1e-04 | +0.28 | 0.008 | 8 | supported | Structure ↗ |
| EGFR | CD2AP | RF2-PPI | -0.44 | 0.001 | -0.05 | 0.678 | 10 | supported | Structure ↗ |
| EGFR | SOS2 PTKc_EGFR #2 | RF2-PPI | -0.49 | 0.003 | +0.35 | 0.015 | 4 | supported | Structure ↗ |
| EGFR | PTPRF | RF2-PPI | +0.44 | 0.003 | -0.16 | 0.061 | 5 | supported | Structure ↗ |
| EGFR | EGFR PTKc_EGFR #2 | PDB | +0.13 | 0.190 | -0.43 | 0.008 | 4 | supported | Structure ↗ |
| EGFR | EGFR PTKc_EGFR | PDB | -0.08 | 0.069 | -0.04 | 0.482 | 11 | supported | Structure ↗ |
| EGFR | ABL1 | AF-M | +0.34 | 0.320 | -0.18 | 0.071 | 4 | not supported | Structure ↗ |
| EGFR | EGF PTKc_EGFR #2 | AF-M | +0.19 | 0.110 | +0.20 | 0.201 | 5 | not supported | Structure ↗ |
| EGFR | NOTCH2 PTKc_EGFR | RF2-PPI | -0.02 | 0.893 | -0.12 | 0.247 | 5 | not supported | Structure ↗ |
| EGFR | TWF1 | RF2-PPI | -0.07 | 0.694 | -0.20 | 0.357 | 3 | not supported | Structure ↗ |
| EGFR | JUP | RF2-PPI | +0.07 | 0.419 | +0.07 | 0.976 | 9 | not supported | Structure ↗ |
| EGFR | ADAMTS9 PTKc_EGFR | RF2-PPI | +0.12 | 0.526 | -0.05 | 0.617 | 6 | not supported | Structure ↗ |
| EGFR | ATP6V1H | RF2-PPI | +0.05 | 0.764 | +0.02 | 0.828 | 4 | not supported | Structure ↗ |
| ERBB2 | VAV1 PTKc_HER2 #2 | RF2-PPI | -0.90 | 1.2e-33 | +0.07 | 0.457 | 7 | supported | Structure ↗ |
| ERBB2 | SH2D3C | RF2-PPI | -0.83 | 1.6e-32 | +0.51 | 0.002 | 9 | supported | Structure ↗ |
| ERBB2 | MEPCE | RF2-PPI | +0.34 | 2.3e-26 | +0.22 | 5.8e-05 | 11 | supported | Structure ↗ |
| ERBB2 | CBLC | RF2-PPI | +0.38 | 5.7e-25 | +0.21 | 4.2e-04 | 8 | supported | Structure ↗ |
| ERBB2 | JMJD4 | RF2-PPI | +0.37 | 6.0e-25 | +0.28 | 7.6e-06 | 8 | supported | Structure ↗ |
| ERBB2 | CPNE3 | RF2-PPI | +0.36 | 2.1e-21 | +0.11 | 0.013 | 14 | supported | Structure ↗ |
| ERBB2 | LRPPRC | RF2-PPI | +0.38 | 4.7e-21 | +0.26 | 7.2e-04 | 7 | supported | Structure ↗ |
| ERBB2 | NXT1 | RF2-PPI | +0.44 | 9.7e-18 | +0.29 | 4.7e-04 | 6 | supported | Structure ↗ |
| ERBB2 | SOCS3 PTKc_HER2 | AF-M | -0.71 | 1.5e-16 | +1.12 | 1.3e-13 | 5 | supported | Structure ↗ |
| ERBB2 | VAV3 | RF2-PPI | -0.65 | 7.6e-14 | -0.01 | 0.451 | 6 | supported | Structure ↗ |
| ERBB2 | ERRFI1 | AF-M | -0.29 | 1.2e-11 | +0.29 | 0.017 | 24 | supported | Structure ↗ |
| ERBB2 | SOCS3 res 948-1141 | AF-M | -0.01 | 0.029 | +0.75 | 2.0e-11 | 6 | supported | Structure ↗ |
| ERBB2 | LRRC15 | RF2-PPI | +0.40 | 2.9e-11 | +0.29 | 0.009 | 3 | supported | Structure ↗ |
| ERBB2 | ERBB3 | RF2-PPI | +0.07 | 0.353 | +0.28 | 2.7e-08 | 25 | supported | Structure ↗ |
| ERBB2 | PC | AF-M | -0.40 | 6.0e-08 | +0.48 | 1.7e-04 | 12 | supported | Structure ↗ |
| ERBB2 | ERBB4 | RF2-PPI | +0.06 | 0.150 | +0.28 | 8.4e-08 | 22 | supported | Structure ↗ |
| ERBB2 | MATK | RF2-PPI | +0.28 | 2.1e-07 | +0.13 | 0.024 | 9 | supported | Structure ↗ |
| ERBB2 | CD44 | RF2-PPI | -0.58 | 4.0e-07 | -0.29 | 0.007 | 5 | supported | Structure ↗ |
| ERBB2 | TIMM50 | RF2-PPI | +0.27 | 3.7e-06 | +0.17 | 0.066 | 4 | supported | Structure ↗ |
| ERBB2 | EGFR | AF-M | +0.04 | 0.008 | +0.23 | 4.4e-05 | 22 | supported | Structure ↗ |
| ERBB2 | VAV1 PTKc_HER2 | RF2-PPI | -0.18 | 0.229 | -0.49 | 9.5e-04 | 4 | supported | Structure ↗ |
| ERBB2 | IQGAP1 | RF2-PPI | -0.30 | 0.001 | +0.17 | 0.557 | 9 | supported | Structure ↗ |
| ERBB2 | VAV2 | RF2-PPI | -0.28 | 0.003 | +0.24 | 0.159 | 8 | supported | Structure ↗ |
| ERBB2 | EGLN3 | RF2-PPI | +0.61 | 0.224 | -0.38 | 0.018 | 3 | supported | Structure ↗ |
| ERBB2 | ANK1 | RF2-PPI | -0.27 | 0.025 | +0.13 | 0.160 | 4 | supported | Structure ↗ |
| ERBB2 | ERBB4 | AF-M | +0.05 | 0.002 | +0.09 | 0.088 | 19 | not supported | Structure ↗ |
| ERBB2 | ERBB3 | AF-M | +0.06 | 0.014 | +0.11 | 0.021 | 19 | not supported | Structure ↗ |
| ERBB2 | GRM1 | AF-M | -0.09 | 0.027 | +0.02 | 0.638 | 7 | not supported | Structure ↗ |
| ERBB2 | NOTCH2 PTKc_HER2 #2 | RF2-PPI | -0.16 | 0.257 | +0.24 | 0.523 | 5 | not supported | Structure ↗ |
| ERBB2 | NOTCH2 PTKc_HER2 | RF2-PPI | -0.07 | 0.697 | +0.04 | 0.976 | 6 | not supported | Structure ↗ |
| GRB2 | LAT2 | AF-M | -1.65 | 7.3e-52 | -0.87 | 2.5e-12 | 8 | supported | Structure ↗ |
| GRB2 | PTPN6 | AF-M | -1.36 | 8.1e-42 | -0.69 | 6.8e-07 | 10 | supported | Structure ↗ |
| GRB2 | SHP2 | AF-M | -1.18 | 2.8e-39 | -0.78 | 1.0e-11 | 11 | supported | Structure ↗ |
| GRB2 | LAT | AF-M | -1.52 | 7.4e-38 | -1.15 | 3.8e-19 | 6 | supported | Structure ↗ |
| GRB2 | GAB3 | RF2-PPI | +0.57 | 3.5e-12 | +0.77 | 6.0e-27 | 13 | supported | Structure ↗ |
| GRB2 | ERRFI1 | AF-M | -0.10 | 0.327 | +1.09 | 1.5e-24 | 5 | supported | Structure ↗ |
| GRB2 | PTPN22 | RF2-PPI | -0.10 | 0.100 | +0.89 | 6.2e-24 | 7 | supported | Structure ↗ |
| GRB2 | PTPN22 | AF-M | -0.67 | 6.6e-24 | +0.16 | 0.013 | 18 | supported | Structure ↗ |
| GRB2 | ARHGAP12 | AF-M | -0.79 | 3.3e-22 | -0.07 | 0.272 | 12 | supported | Structure ↗ |
| GRB2 | TNK2 | AF-M | -0.80 | 8.0e-20 | -0.05 | 0.133 | 8 | supported | Structure ↗ |
| GRB2 | GAB2 | PDB | +1.21 | 9.0e-19 | +0.51 | 2.0e-05 | 6 | supported | Structure ↗ |
| GRB2 | BTK SH2_GRB2_like | AF-M | -1.32 | 6.7e-18 | -0.55 | 2.1e-05 | 4 | supported | Structure ↗ |
| GRB2 | NTRK3 SH2_GRB2_like | AF-M | -0.80 | 1.2e-17 | -0.78 | 1.1e-14 | 8 | supported | Structure ↗ |
| GRB2 | DLGAP1 | AF-M | -0.48 | 0.002 | +0.85 | 1.4e-15 | 5 | supported | Structure ↗ |
| GRB2 | THEMIS | AF-M | +0.58 | 3.6e-15 | +0.56 | 1.6e-10 | 15 | supported | Structure ↗ |
| GRB2 | DCTN1 | AF-M | -0.32 | 2.6e-07 | +0.81 | 3.7e-15 | 6 | supported | Structure ↗ |
| GRB2 | PAK2 | RF2-PPI | -0.00 | 0.814 | +0.56 | 7.7e-15 | 19 | supported | Structure ↗ |
| GRB2 | ARHGAP9 | AF-M | -0.72 | 3.8e-14 | -0.19 | 4.5e-06 | 10 | supported | Structure ↗ |
| GRB2 | RAPGEF1 | RF2-PPI | +0.01 | 0.714 | +0.81 | 4.7e-14 | 4 | supported | Structure ↗ |
| GRB2 | REPS2 | RF2-PPI | -0.00 | 0.821 | +0.80 | 1.2e-13 | 4 | supported | Structure ↗ |
| GRB2 | GRB2 SH2_GRB2_like | PDB | +0.50 | 4.7e-11 | -0.12 | 0.013 | 15 | supported | Structure ↗ |
| GRB2 | GAB2 | AF-M | -0.21 | 0.011 | +0.36 | 1.0e-10 | 16 | supported | Structure ↗ |
| GRB2 | VAV3 | AF-M | +0.69 | 1.8e-10 | +0.43 | 1.3e-07 | 9 | supported | Structure ↗ |
| GRB2 | GRB2 SH2_GRB2_like #3 | PDB | -0.59 | 1.6e-08 | +0.58 | 2.4e-07 | 8 | supported | Structure ↗ |
| GRB2 | PAK1 | AF-M | -0.43 | 2.1e-08 | -0.20 | 0.596 | 18 | supported | Structure ↗ |
| GRB2 | REPS1 | RF2-PPI | -0.12 | 0.193 | +0.54 | 4.7e-08 | 6 | supported | Structure ↗ |
| GRB2 | Vav1 | PDB | +0.55 | 1.0e-06 | +0.57 | 5.5e-08 | 9 | supported | Structure ↗ |
| GRB2 | DOCK1 | AF-M | -0.54 | 4.3e-07 | -0.23 | 0.556 | 8 | supported | Structure ↗ |
| GRB2 | THEMIS | PDB | +0.07 | 0.949 | +0.44 | 2.7e-06 | 13 | supported | Structure ↗ |
| GRB2 | GRB2 SH2_GRB2_like #2 | PDB | +0.40 | 3.6e-06 | -0.39 | 2.2e-04 | 6 | supported | Structure ↗ |
| GRB2 | NTRK3 SH3_GRB2_C | AF-M | -0.49 | 0.001 | +0.24 | 0.142 | 5 | supported | Structure ↗ |
| GRB2 | BTK SH3_GRB2_C | AF-M | +0.12 | 0.079 | +0.32 | 0.005 | 4 | supported | Structure ↗ |
| GRB2 | LRRK1 | AF-M | +0.17 | 0.165 | +0.13 | 0.123 | 8 | supported | Structure ↗ |
| KRAS | IL1RAP | AF-M | -0.86 | 1.2e-54 | +0.40 | 0.061 | 9 | supported | Structure ↗ |
| KRAS | RAPGEF2 | AF-M | -0.44 | 1.3e-46 | +0.58 | 6.4e-11 | 24 | supported | Structure ↗ |
| KRAS | SNAP47 | AF-M | -0.94 | 9.7e-42 | -0.16 | 0.002 | 6 | supported | Structure ↗ |
| KRAS | TTC4 | AF-M | -0.28 | 1.0e-07 | +2.11 | 1.6e-41 | 6 | supported | Structure ↗ |
| KRAS | PTPN1 H_N_K_Ras_like #2 | AF-M | -0.80 | 5.0e-41 | +0.21 | 0.789 | 8 | supported | Structure ↗ |
| KRAS | PIK3R4 | AF-M | -0.69 | 2.6e-40 | +0.90 | 2.0e-21 | 12 | supported | Structure ↗ |
| KRAS | RPS10 | AF-M | -0.46 | 2.0e-16 | +1.50 | 4.0e-40 | 9 | supported | Structure ↗ |
| KRAS | AFDN | AF-M | -0.73 | 8.1e-40 | +0.61 | 2.0e-07 | 11 | supported | Structure ↗ |
| KRAS | DCUN1D3 | RF2-PPI | -1.30 | 9.0e-40 | -0.16 | 0.023 | 5 | supported | Structure ↗ |
| KRAS | USO1 | AF-M | -0.73 | 1.5e-39 | +1.47 | 2.1e-35 | 10 | supported | Structure ↗ |
| KRAS | RIN1 | AF-M | -0.76 | 2.9e-39 | +0.37 | 5.0e-05 | 6 | supported | Structure ↗ |
| KRAS | CYFIP1 | AF-M | -0.77 | 4.1e-39 | +0.45 | 0.010 | 9 | supported | Structure ↗ |
| KRAS | EXOSC5 | AF-M | -0.55 | 7.1e-26 | +1.43 | 6.2e-38 | 10 | supported | Structure ↗ |
| KRAS | SOS1 H_N_K_Ras_like #2 | AF-M | -0.65 | 4.5e-37 | +0.07 | 0.365 | 16 | supported | Structure ↗ |
| KRAS | FRMPD1 | AF-M | -0.83 | 1.4e-36 | +0.45 | 0.012 | 8 | supported | Structure ↗ |
| KRAS | PIK3CB | AF-M | -0.77 | 1.5e-36 | +0.14 | 0.524 | 7 | supported | Structure ↗ |
| KRAS | LRP8 | AF-M | -0.26 | 1.0e-05 | +2.22 | 5.9e-36 | 4 | supported | Structure ↗ |
| KRAS | RAPGEF6 | AF-M | -0.41 | 8.3e-36 | +0.60 | 2.2e-10 | 19 | supported | Structure ↗ |
| KRAS | SOS1 H_N_K_Ras_like | AF-M | -0.31 | 1.7e-35 | +0.53 | 2.4e-08 | 20 | supported | Structure ↗ |
| KRAS | RGL2 | PDB | -0.66 | 8.0e-35 | -0.09 | 0.032 | 10 | supported | Structure ↗ |
| KRAS | EEF1AKMT1 | AF-M | -0.80 | 8.2e-35 | -0.48 | 1.1e-09 | 7 | supported | Structure ↗ |
| KRAS | RRAS2 H_N_K_Ras_like | AF-M | -0.80 | 1.3e-33 | +0.10 | 0.444 | 8 | supported | Structure ↗ |
| KRAS | BRAF | PDB | -0.72 | 5.3e-33 | +0.27 | 0.160 | 7 | supported | Structure ↗ |
| KRAS | EIF2S2 | AF-M | -0.73 | 6.3e-33 | +0.18 | 0.403 | 6 | supported | Structure ↗ |
| KRAS | RASGEF1C | AF-M | -0.30 | 9.5e-33 | +0.79 | 1.9e-20 | 18 | supported | Structure ↗ |
| KRAS | RASGEF1A | AF-M | -0.39 | 5.4e-28 | +1.12 | 3.6e-32 | 14 | supported | Structure ↗ |
| KRAS | SIPA1L1 H_N_K_Ras_like #3 | AF-M | -0.50 | 7.1e-32 | +0.41 | 1.9e-04 | 15 | supported | Structure ↗ |
| KRAS | NRAS | AF-M | -0.67 | 7.4e-32 | +0.18 | 0.440 | 10 | supported | Structure ↗ |
| KRAS | MAPKAP1 H_N_K_Ras_like | PDB | -0.61 | 7.8e-32 | +0.48 | 8.7e-06 | 10 | supported | Structure ↗ |
| KRAS | TIAM1 | AF-M | -0.40 | 1.3e-31 | +1.00 | 2.2e-18 | 12 | supported | Structure ↗ |
| KRAS | MAD2L1 H_N_K_Ras_like | AF-M | -0.32 | 1.7e-04 | +1.25 | 2.1e-31 | 9 | supported | Structure ↗ |
| KRAS | NRXN3 | AF-M | -0.83 | 6.7e-31 | -0.05 | 0.046 | 7 | supported | Structure ↗ |
| KRAS | CRAF | PDB | -0.71 | 8.5e-31 | +0.29 | 0.022 | 7 | supported | Structure ↗ |
| KRAS | KRAS H_N_K_Ras_like #3 | PDB | -0.72 | 8.8e-31 | +0.16 | 0.524 | 6 | supported | Structure ↗ |
| KRAS | ADGRG1 | AF-M | -0.31 | 1.4e-11 | +1.22 | 9.5e-31 | 8 | supported | Structure ↗ |
| KRAS | DAB2IP | AF-M | -0.77 | 1.3e-30 | +0.31 | 0.095 | 10 | supported | Structure ↗ |
| KRAS | ITSN1 | AF-M | -0.38 | 4.6e-30 | +0.75 | 1.4e-07 | 9 | supported | Structure ↗ |
| KRAS | TAOK3 | AF-M | -0.42 | 4.0e-12 | +1.41 | 8.1e-30 | 7 | supported | Structure ↗ |
| KRAS | HRAS | AF-M | -0.65 | 9.2e-30 | +0.12 | 0.561 | 12 | supported | Structure ↗ |
| KRAS | EXOC1 | AF-M | -0.62 | 1.9e-29 | +0.68 | 1.0e-07 | 8 | supported | Structure ↗ |
| KRAS | NME6 H_N_K_Ras_like #2 | AF-M | -0.26 | 9.8e-18 | +1.29 | 3.8e-29 | 10 | supported | Structure ↗ |
| KRAS | YKT6 | AF-M | -0.24 | 6.8e-14 | +1.46 | 8.7e-29 | 8 | supported | Structure ↗ |
| KRAS | RAP2C | AF-M | -0.64 | 1.3e-28 | +0.21 | 0.403 | 12 | supported | Structure ↗ |
| KRAS | MCF2L | AF-M | -0.36 | 2.2e-27 | +1.00 | 2.8e-16 | 11 | supported | Structure ↗ |
| KRAS | CRAF | AF-M | -0.51 | 4.1e-27 | +0.04 | 0.195 | 15 | supported | Structure ↗ |
| KRAS | RAPH1 | AF-M | -0.66 | 4.9e-27 | +0.26 | 0.104 | 7 | supported | Structure ↗ |
| KRAS | MAPKAP1 | AF-M | -0.49 | 6.7e-27 | +1.08 | 1.7e-22 | 12 | supported | Structure ↗ |
| KRAS | ATP5F1A | AF-M | -0.58 | 6.7e-27 | +0.92 | 3.5e-17 | 12 | supported | Structure ↗ |
| KRAS | PIK3CA | AF-M | -0.58 | 8.4e-26 | +0.23 | 0.099 | 10 | supported | Structure ↗ |
| KRAS | PTPN14 | RF2-PPI | -0.60 | 1.3e-25 | +0.04 | 0.723 | 11 | supported | Structure ↗ |
| KRAS | UTP6 | AF-M | -0.31 | 3.5e-10 | +1.12 | 1.3e-25 | 11 | supported | Structure ↗ |
| KRAS | ARAF | AF-M | -0.50 | 2.1e-25 | +0.07 | 0.437 | 15 | supported | Structure ↗ |
| KRAS | BRAF | AF-M | -0.53 | 4.3e-25 | +0.07 | 0.880 | 12 | supported | Structure ↗ |
| KRAS | KIF11 | AF-M | -0.75 | 7.7e-25 | -0.21 | 5.4e-04 | 7 | supported | Structure ↗ |
| KRAS | USE1 | AF-M | -0.38 | 4.9e-10 | +1.52 | 9.0e-25 | 5 | supported | Structure ↗ |
| KRAS | RASGRF2 | AF-M | -0.13 | 1.0e-24 | +0.30 | 0.006 | 22 | supported | Structure ↗ |
| KRAS | RAP1A | AF-M | -0.60 | 1.0e-24 | +0.14 | 0.213 | 11 | supported | Structure ↗ |
| KRAS | NME6 H_N_K_Ras_like | AF-M | -0.80 | 1.4e-24 | +1.15 | 4.6e-12 | 6 | supported | Structure ↗ |
| KRAS | RASAL2 | AF-M | -0.04 | 3.7e-24 | +0.35 | 0.024 | 10 | supported | Structure ↗ |
| KRAS | NPM1 | AF-M | -0.62 | 7.8e-24 | +0.88 | 1.1e-14 | 10 | supported | Structure ↗ |
| KRAS | LZTR1 | PDB | -0.24 | 8.1e-24 | +0.62 | 4.7e-11 | 13 | supported | Structure ↗ |
| KRAS | PTPN1 H_N_K_Ras_like | AF-M | -0.38 | 5.2e-23 | +0.35 | 0.018 | 10 | supported | Structure ↗ |
| KRAS | YWHAE | RF2-PPI | -0.88 | 9.0e-23 | +0.89 | 4.8e-07 | 5 | supported | Structure ↗ |
| KRAS | RASGRF1 | AF-M | -0.00 | 2.5e-22 | +0.41 | 4.6e-06 | 21 | supported | Structure ↗ |
| KRAS | WBP4 | AF-M | -0.56 | 4.2e-22 | +0.16 | 0.278 | 8 | supported | Structure ↗ |
| KRAS | RALGPS2 | AF-M | +0.09 | 4.7e-21 | +0.47 | 8.0e-06 | 17 | supported | Structure ↗ |
| KRAS | TRIO H_N_K_Ras_like | AF-M | -0.17 | 2.8e-17 | +1.06 | 9.2e-21 | 10 | supported | Structure ↗ |
| KRAS | C2orf72 H_N_K_Ras_like | AF-M | -0.50 | 1.6e-13 | +1.57 | 3.0e-20 | 4 | supported | Structure ↗ |
| KRAS | FGD6 | AF-M | -0.32 | 3.4e-20 | +0.68 | 4.9e-06 | 8 | supported | Structure ↗ |
| KRAS | FGD1 | AF-M | -0.22 | 1.1e-19 | +0.83 | 2.8e-11 | 10 | supported | Structure ↗ |
| KRAS | RGL2 | AF-M | +0.08 | 6.3e-19 | +0.29 | 0.012 | 26 | supported | Structure ↗ |
| KRAS | PLAAT3 | PDB | +1.30 | 1.3e-08 | -0.81 | 1.9e-18 | 9 | supported | Structure ↗ |
| KRAS | OSBPL10 H_N_K_Ras_like #2 | AF-M | -0.63 | 2.1e-18 | +0.63 | 1.2e-06 | 6 | supported | Structure ↗ |
| KRAS | ARHGAP39 H_N_K_Ras_like #2 | AF-M | -0.61 | 1.5e-13 | +1.53 | 2.4e-18 | 4 | supported | Structure ↗ |
| KRAS | RALGDS | AF-M | +0.14 | 7.1e-18 | +0.37 | 0.003 | 24 | supported | Structure ↗ |
| KRAS | SGSM2 | AF-M | -0.06 | 1.8e-17 | +0.58 | 3.6e-08 | 13 | supported | Structure ↗ |
| KRAS | C2orf72 H_N_K_Ras_like #2 | AF-M | -0.00 | 3.0e-06 | +0.95 | 1.9e-17 | 9 | supported | Structure ↗ |
| KRAS | ARHGDIA | AF-M | -0.27 | 1.6e-12 | +0.98 | 3.3e-17 | 9 | supported | Structure ↗ |
| KRAS | TBC1D10B | AF-M | +0.11 | 7.7e-17 | +0.51 | 3.2e-05 | 15 | supported | Structure ↗ |
| KRAS | SLC4A2 | RF2-PPI | -0.97 | 9.0e-17 | -0.52 | 0.003 | 3 | supported | Structure ↗ |
| KRAS | TBC1D10A | AF-M | +0.15 | 1.1e-16 | +0.68 | 6.9e-08 | 14 | supported | Structure ↗ |
| KRAS | RASGRP4 | AF-M | +0.18 | 1.7e-14 | +0.30 | 0.031 | 23 | supported | Structure ↗ |
| KRAS | TBC1D5 | AF-M | -0.14 | 3.4e-14 | +0.67 | 7.9e-05 | 11 | supported | Structure ↗ |
| KRAS | ATP5F1B H_N_K_Ras_like | AF-M | -0.47 | 1.1e-13 | -0.04 | 0.006 | 6 | supported | Structure ↗ |
| KRAS | SOS1 | PDB | +0.15 | 2.7e-13 | +0.46 | 3.3e-07 | 22 | supported | Structure ↗ |
| KRAS | OSBPL10 H_N_K_Ras_like | AF-M | -0.47 | 2.7e-13 | +0.39 | 0.011 | 4 | supported | Structure ↗ |
| KRAS | RASGRP1 | AF-M | +0.22 | 5.7e-12 | +0.30 | 0.027 | 23 | supported | Structure ↗ |
| KRAS | RGL1 | AF-M | +0.17 | 1.0e-11 | +0.26 | 0.028 | 21 | supported | Structure ↗ |
| KRAS | RBM12 | AF-M | -0.24 | 2.0e-11 | +0.36 | 2.9e-04 | 14 | supported | Structure ↗ |
| KRAS | ZDHHC5 | AF-M | -0.44 | 6.8e-11 | -0.36 | 1.2e-04 | 5 | supported | Structure ↗ |
| KRAS | RASGRP3 | AF-M | +0.28 | 3.2e-10 | +0.32 | 0.015 | 21 | supported | Structure ↗ |
| KRAS | SIPA1L2 | AF-M | +0.45 | 3.5e-10 | +0.25 | 0.185 | 14 | supported | Structure ↗ |
| KRAS | ARHGAP32 | AF-M | -0.06 | 5.4e-10 | +0.63 | 1.1e-06 | 8 | supported | Structure ↗ |
| KRAS | KRAS H_N_K_Ras_like | PDB | +0.18 | 6.1e-10 | -0.08 | 0.234 | 7 | supported | Structure ↗ |
| KRAS | ARHGAP31 | AF-M | -0.16 | 1.3e-06 | +0.70 | 2.1e-09 | 9 | supported | Structure ↗ |
| KRAS | PPIA | PDB | -0.39 | 3.1e-09 | +0.09 | 0.023 | 4 | supported | Structure ↗ |
| KRAS | SIPA1L1 H_N_K_Ras_like | AF-M | -0.60 | 6.6e-09 | +0.01 | 0.432 | 4 | supported | Structure ↗ |
| KRAS | RASA1 | AF-M | +0.23 | 5.3e-08 | -0.16 | 0.006 | 15 | supported | Structure ↗ |
| KRAS | KRAS H_N_K_Ras_like #2 | PDB | -0.55 | 8.2e-08 | -0.17 | 0.093 | 4 | supported | Structure ↗ |
| KRAS | PLXNA1 | AF-M | +0.39 | 8.9e-06 | -0.32 | 9.4e-08 | 14 | supported | Structure ↗ |
| KRAS | ATP5F1B H_N_K_Ras_like #2 | AF-M | -0.40 | 7.9e-07 | +0.04 | 0.712 | 3 | supported | Structure ↗ |
| KRAS | PLXNC1 | AF-M | +0.26 | 1.3e-06 | -0.10 | 0.005 | 20 | supported | Structure ↗ |
| KRAS | SIPA1L1 H_N_K_Ras_like #2 | AF-M | +0.45 | 2.6e-06 | +0.22 | 0.327 | 14 | supported | Structure ↗ |
| KRAS | PLXNB2 | AF-M | +0.39 | 2.6e-05 | -0.08 | 0.017 | 16 | supported | Structure ↗ |
| KRAS | FAM91A1 | AF-M | +1.15 | 0.021 | +0.62 | 3.6e-05 | 7 | supported | Structure ↗ |
| KRAS | PLXNA2 | AF-M | +0.43 | 4.0e-04 | -0.24 | 1.5e-04 | 15 | supported | Structure ↗ |
| KRAS | CHN1 | AF-M | +0.90 | 1.7e-04 | -0.31 | 9.9e-04 | 6 | supported | Structure ↗ |
| KRAS | CHERP | AF-M | -0.40 | 1.9e-04 | -0.03 | 0.096 | 4 | supported | Structure ↗ |
| KRAS | NF1 | AF-M | +0.55 | 2.3e-04 | +0.03 | 0.358 | 12 | supported | Structure ↗ |
| KRAS | ARHGAP21 | AF-M | +0.89 | 2.4e-04 | +0.01 | 8.6e-04 | 11 | supported | Structure ↗ |
| KRAS | IQGAP1 | AF-M | +0.53 | 4.2e-04 | +0.27 | 0.098 | 9 | supported | Structure ↗ |
| KRAS | MAD2L1 res 2-184 | AF-M | -0.16 | 0.176 | +0.38 | 6.0e-04 | 8 | supported | Structure ↗ |
| KRAS | TRIO H_N_K_Ras_like #2 | AF-M | +0.98 | 0.159 | -0.26 | 7.5e-04 | 6 | supported | Structure ↗ |
| KRAS | PPP1CA | PDB | -0.34 | 9.3e-04 | -0.22 | 0.020 | 4 | supported | Structure ↗ |
| KRAS | RRAS2 H_N_K_Ras_like #2 | AF-M | -0.03 | 0.008 | -0.26 | 0.001 | 8 | supported | Structure ↗ |
| KRAS | RALGAPA2 | AF-M | +0.44 | 0.003 | -0.04 | 0.433 | 10 | supported | Structure ↗ |
| KRAS | USP6NL | AF-M | +0.61 | 0.022 | +0.11 | 0.206 | 10 | supported | Structure ↗ |
| KRAS | ARHGAP39 H_N_K_Ras_like | AF-M | +0.59 | 0.055 | +0.26 | 0.054 | 8 | supported | Structure ↗ |
| KRAS | RGL3 | AF-M | +0.07 | 2.5e-19 | +0.23 | 0.236 | 23 | not supported | Structure ↗ |
| KRAS | MAPKAP1 H_N_K_Ras_like #2 | PDB | -0.30 | 0.110 | -0.17 | 0.069 | 4 | not supported | Structure ↗ |
| KRAS | RALGAPA1 | AF-M | +0.69 | 0.218 | +0.05 | 0.618 | 7 | not supported | Structure ↗ |
| KSR1 | MEK1 | AF-M | +1.78 | 6.4e-75 | -0.89 | 2.6e-37 | 18 | supported | Structure ↗ |
| KSR1 | MEK2 | AF-M | +1.88 | 6.2e-71 | -0.90 | 1.1e-36 | 18 | supported | Structure ↗ |
| KSR1 | DEPDC1B | AF-M | +2.41 | 1.6e-61 | -1.15 | 2.2e-35 | 11 | supported | Structure ↗ |
| KSR1 | MEK1 | PDB | +1.23 | 8.1e-42 | -0.63 | 1.1e-21 | 15 | supported | Structure ↗ |
| KSR1 | KCTD3 STKc_KSR1 | AF-M | +2.09 | 4.6e-26 | -0.65 | 1.9e-10 | 9 | supported | Structure ↗ |
| KSR1 | DCAF1 STKc_KSR1 #2 | AF-M | -0.51 | 8.2e-19 | +0.37 | 2.0e-09 | 11 | supported | Structure ↗ |
| KSR1 | KCTD3 STKc_KSR1 #2 | AF-M | -0.52 | 3.1e-10 | +0.16 | 0.434 | 4 | supported | Structure ↗ |
| KSR1 | CRAF | AF-M | -0.05 | 0.165 | -0.46 | 8.5e-06 | 10 | supported | Structure ↗ |
| KSR1 | RASAL2 | AF-M | -0.51 | 3.2e-05 | +0.54 | 0.034 | 3 | supported | Structure ↗ |
| KSR1 | BRAF | AF-M | -0.15 | 0.068 | -0.33 | 6.8e-05 | 10 | supported | Structure ↗ |
| KSR1 | BRAF | RF2-PPI | -0.05 | 0.600 | -0.37 | 2.7e-04 | 10 | supported | Structure ↗ |
| KSR1 | KSR2 | AF-M | -0.14 | 0.002 | -0.37 | 0.001 | 9 | supported | Structure ↗ |
| KSR1 | ARAF | AF-M | -0.10 | 0.022 | -0.24 | 0.004 | 11 | supported | Structure ↗ |
| KSR1 | DCAF1 STKc_KSR1 | AF-M | -0.13 | 0.673 | +0.28 | 0.011 | 4 | supported | Structure ↗ |
| KSR2 | MEK1 | AF-M | +0.92 | 8.5e-51 | -0.84 | 1.1e-38 | 16 | supported | Structure ↗ |
| KSR2 | MEK2 | AF-M | +0.92 | 3.7e-49 | -0.84 | 6.2e-38 | 17 | supported | Structure ↗ |
| KSR2 | KSR1 | AF-M | -0.69 | 1.2e-36 | +0.61 | 1.8e-12 | 18 | supported | Structure ↗ |
| KSR2 | MEK1 | PDB | +0.53 | 1.8e-21 | -0.74 | 2.1e-35 | 18 | supported | Structure ↗ |
| KSR2 | BRAF | AF-M | -0.66 | 5.2e-33 | +0.58 | 1.6e-10 | 20 | supported | Structure ↗ |
| KSR2 | PRKAA1 res 22-687 | AF-M | -0.66 | 2.5e-26 | +1.12 | 4.6e-10 | 15 | supported | Structure ↗ |
| KSR2 | SOX2 | AF-M | -1.00 | 2.2e-24 | +0.83 | 1.4e-12 | 5 | supported | Structure ↗ |
| KSR2 | FBXL2 | RF2-PPI | -1.02 | 2.8e-23 | +0.22 | 0.051 | 4 | supported | Structure ↗ |
| KSR2 | BRAF | RF2-PPI | -0.72 | 8.1e-23 | +0.59 | 1.1e-12 | 11 | supported | Structure ↗ |
| KSR2 | ARAF | AF-M | -0.63 | 8.2e-22 | +0.57 | 4.1e-11 | 14 | supported | Structure ↗ |
| KSR2 | CRAF | AF-M | -0.62 | 4.9e-19 | +0.55 | 4.0e-10 | 11 | supported | Structure ↗ |
| KSR2 | BRAF SAM_KSR1_N | RF2-PPI | -0.37 | 1.7e-06 | – | – | 10 | supported | Structure ↗ |
| KSR2 | PRKAA1 res 469-776 | AF-M | -0.44 | 9.8e-05 | +0.13 | 0.774 | 7 | supported | Structure ↗ |
| KSR2 | CDC27 | RF2-PPI | -0.03 | 0.782 | – | – | 5 | not supported | Structure ↗ |
| MEK1 | KSR1 | PDB | -0.24 | 1.5e-10 | +0.05 | 0.290 | 16 | supported | Structure ↗ |
| MEK1 | MAPK1 | RF2-PPI | +0.20 | 1.7e-08 | -0.13 | 0.628 | 7 | supported | Structure ↗ |
| MEK1 | MEK1 PKc_MAP2K1 | PDB | +0.16 | 1.3e-07 | -0.05 | 0.623 | 12 | supported | Structure ↗ |
| MEK1 | PLEKHF2 | RF2-PPI | +0.43 | 2.0e-07 | +0.06 | 0.976 | 3 | supported | Structure ↗ |
| MEK1 | MEK2 | AF-M | +0.26 | 3.2e-06 | -0.07 | 0.494 | 12 | supported | Structure ↗ |
| MEK1 | KSR1 | AF-M | -0.24 | 9.2e-06 | +0.06 | 0.290 | 16 | supported | Structure ↗ |
| MEK1 | MAPK1 | AF-M | +0.16 | 9.7e-06 | -0.03 | 0.379 | 12 | supported | Structure ↗ |
| MEK1 | MAP3K1 | RF2-PPI | +0.24 | 1.5e-05 | -0.12 | 0.159 | 11 | supported | Structure ↗ |
| MEK1 | KSR2 | AF-M | -0.21 | 3.7e-05 | +0.03 | 0.523 | 14 | supported | Structure ↗ |
| MEK1 | KSR2 | PDB | -0.18 | 3.8e-05 | +0.01 | 0.687 | 15 | supported | Structure ↗ |
| MEK1 | BRAF | AF-M | -0.23 | 3.9e-05 | +0.04 | 0.400 | 12 | supported | Structure ↗ |
| MEK1 | CRAF | AF-M | -0.23 | 1.6e-04 | +0.05 | 0.446 | 12 | supported | Structure ↗ |
| MEK1 | PEBP4 | RF2-PPI | -0.26 | 0.001 | -0.24 | 0.019 | 5 | supported | Structure ↗ |
| MEK1 | ARAF | AF-M | -0.18 | 0.001 | +0.04 | 0.451 | 14 | supported | Structure ↗ |
| MEK1 | CRAF | PDB | -0.15 | 1.4e-06 | +0.05 | 0.173 | 15 | not supported | Structure ↗ |
| MEK1 | MEK1 PKc_MAP2K1 #2 | PDB | +0.10 | 8.9e-05 | -0.07 | 0.870 | 10 | not supported | Structure ↗ |
| MEK1 | MAPK3 | AF-M | +0.13 | 1.8e-04 | +0.07 | 0.173 | 12 | not supported | Structure ↗ |
| MEK1 | BRAF | PDB | -0.15 | 2.6e-04 | +0.07 | 0.253 | 18 | not supported | Structure ↗ |
| MEK1 | CRAF | RF2-PPI | -0.16 | 0.001 | +0.06 | 0.432 | 10 | not supported | Structure ↗ |
| MEK1 | TRIB1 | RF2-PPI | +0.05 | 0.010 | +0.02 | 0.739 | 5 | not supported | Structure ↗ |
| MEK1 | MAPK3 | RF2-PPI | +0.04 | 0.029 | -0.13 | 1.000 | 6 | not supported | Structure ↗ |
| MEK1 | MAP3K8 | AF-M | -0.16 | 0.029 | +0.03 | 0.503 | 9 | not supported | Structure ↗ |
| MEK1 | MAP3K8 | RF2-PPI | +0.08 | 0.053 | -0.17 | 0.249 | 7 | not supported | Structure ↗ |
| MEK1 | MAP3K1 | AF-M | +0.02 | 0.073 | -0.11 | 0.455 | 8 | not supported | Structure ↗ |
| MEK1 | MAP2K6 | AF-M | -0.02 | 0.087 | -0.11 | 0.579 | 5 | not supported | Structure ↗ |
| MEK1 | MAPK3 | PDB | +0.01 | 0.101 | -0.03 | 0.870 | 22 | not supported | Structure ↗ |
| MEK1 | 14-3-3zeta | PDB | -0.10 | 0.101 | -0.16 | 0.434 | 4 | not supported | Structure ↗ |
| MEK1 | MAP3K2 | RF2-PPI | +0.09 | 0.130 | -0.12 | 0.229 | 13 | not supported | Structure ↗ |
| MEK1 | MEK1 PKc_MAP2K1 #3 | PDB | -0.08 | 0.154 | +0.04 | 0.732 | 6 | not supported | Structure ↗ |
| MEK1 | MAP3K3 | RF2-PPI | -0.08 | 0.159 | -0.05 | 0.898 | 10 | not supported | Structure ↗ |
| MEK1 | STK11 | AF-M | +0.04 | 0.171 | -0.06 | 0.816 | 7 | not supported | Structure ↗ |
| MEK1 | MEK1 PKc_MAP2K1 #4 | PDB | -0.05 | 0.173 | +0.09 | 0.358 | 5 | not supported | Structure ↗ |
| MEK1 | ARAF | RF2-PPI | -0.15 | 0.203 | -0.01 | 0.877 | 8 | not supported | Structure ↗ |
| MEK1 | MAP3K4 | AF-M | -0.05 | 0.209 | -0.05 | 0.866 | 8 | not supported | Structure ↗ |
| MEK1 | MAP3K7 | AF-M | +0.00 | 0.257 | +0.05 | 0.344 | 17 | not supported | Structure ↗ |
| MEK1 | WDR83 | AF-M | -0.11 | 0.260 | -0.14 | 0.444 | 11 | not supported | Structure ↗ |
| MEK1 | WNK1 | AF-M | -0.05 | 0.730 | -0.17 | 0.324 | 6 | not supported | Structure ↗ |
| MEK1 | GRK2 | RF2-PPI | +0.09 | 0.456 | -0.14 | 0.917 | 4 | not supported | Structure ↗ |
| MEK1 | BRAF | RF2-PPI | +0.06 | 0.998 | -0.07 | 0.572 | 10 | not supported | Structure ↗ |
| MEK2 | MAP2K5 PKc_MAP2K2 #2 | AF-M | +0.73 | 2.3e-09 | +0.37 | 0.019 | 3 | supported | Structure ↗ |
| MEK2 | MAP2K5 PKc_MAP2K2 | AF-M | +0.53 | 6.6e-08 | +0.30 | 0.120 | 3 | supported | Structure ↗ |
| MEK2 | CRAF | AF-M | -0.26 | 7.4e-07 | +0.16 | 0.117 | 15 | supported | Structure ↗ |
| MEK2 | BRAF | AF-M | -0.21 | 1.5e-05 | +0.20 | 0.034 | 13 | supported | Structure ↗ |
| MEK2 | STK26 | AF-M | -0.33 | 1.6e-05 | +0.14 | 0.319 | 11 | supported | Structure ↗ |
| MEK2 | KSR2 | AF-M | -0.25 | 5.4e-05 | +0.10 | 0.487 | 15 | supported | Structure ↗ |
| MEK2 | RHOBTB2 | RF2-PPI | +0.28 | 8.2e-05 | +0.27 | 0.080 | 4 | supported | Structure ↗ |
| MEK2 | ARAF | AF-M | -0.22 | 1.5e-04 | +0.15 | 0.217 | 15 | supported | Structure ↗ |
| MEK2 | KSR1 | AF-M | -0.22 | 5.4e-04 | +0.14 | 0.229 | 17 | supported | Structure ↗ |
| MEK2 | MEK1 | AF-M | +0.26 | 0.001 | +0.13 | 0.523 | 12 | supported | Structure ↗ |
| MEK2 | MAPK8 | AF-M | -0.27 | 0.002 | +0.07 | 0.963 | 8 | supported | Structure ↗ |
| MEK2 | MAP3K2 | RF2-PPI | -0.22 | 0.012 | +0.12 | 0.700 | 6 | supported | Structure ↗ |
| MEK2 | MAPK3 | RF2-PPI | +0.13 | 0.031 | +0.24 | 0.019 | 8 | supported | Structure ↗ |
| MEK2 | MAPK1 | AF-M | -0.02 | 0.036 | +0.14 | 0.095 | 11 | supported | Structure ↗ |
| MEK2 | MAP4K5 | AF-M | -0.03 | 0.065 | +0.12 | 0.451 | 10 | supported | Structure ↗ |
| MEK2 | MEK2 | PDB | +0.01 | 8.0e-05 | +0.15 | 0.180 | 12 | not supported | Structure ↗ |
| MEK2 | CRAF | RF2-PPI | -0.19 | 0.002 | +0.13 | 0.168 | 18 | not supported | Structure ↗ |
| MEK2 | BRAF | RF2-PPI | -0.14 | 0.009 | +0.15 | 0.340 | 11 | not supported | Structure ↗ |
| MEK2 | MAP3K1 | RF2-PPI | -0.04 | 0.012 | +0.08 | 0.945 | 11 | not supported | Structure ↗ |
| MEK2 | MAPK3 | AF-M | -0.12 | 0.014 | +0.18 | 0.088 | 11 | not supported | Structure ↗ |
| MEK2 | MAP3K7 | AF-M | -0.13 | 0.024 | +0.18 | 0.062 | 18 | not supported | Structure ↗ |
| MEK2 | BBS7 | RF2-PPI | +0.19 | 0.028 | +0.01 | 0.467 | 10 | not supported | Structure ↗ |
| MEK2 | MAPK1 | RF2-PPI | +0.14 | 0.059 | +0.20 | 0.103 | 6 | not supported | Structure ↗ |
| MEK2 | ARAF | RF2-PPI | -0.09 | 0.065 | +0.09 | 0.401 | 17 | not supported | Structure ↗ |
| MEK2 | MOS | AF-M | -0.02 | 0.110 | +0.12 | 0.401 | 11 | not supported | Structure ↗ |
| MEK2 | PGRMC1 | RF2-PPI | +0.10 | 0.258 | +0.16 | 0.266 | 7 | not supported | Structure ↗ |
| MEK2 | MOS | RF2-PPI | -0.02 | 0.673 | +0.17 | 0.267 | 8 | not supported | Structure ↗ |
| MEK2 | WDR83 | AF-M | -0.06 | 0.364 | -0.01 | 0.305 | 11 | not supported | Structure ↗ |
| MEK2 | MAP2K3 | AF-M | +0.04 | 0.422 | +0.09 | 0.784 | 7 | not supported | Structure ↗ |
| MEK2 | MAPK8 | RF2-PPI | -0.13 | 0.470 | -0.00 | 0.465 | 14 | not supported | Structure ↗ |
| HGFR | HGFR PTKc_MET_Ron #2 | PDB | +0.65 | 4.6e-14 | -0.32 | 9.7e-04 | 10 | supported | Structure ↗ |
| HGFR | HGFR PTKc_MET_Ron #3 | PDB | +0.65 | 1.4e-11 | -0.32 | 0.002 | 9 | supported | Structure ↗ |
| HGFR | HGF PTKc_MET_Ron | AF-M | -0.52 | 1.8e-07 | +0.83 | 9.6e-11 | 4 | supported | Structure ↗ |
| HGFR | HGFR PTKc_MET_Ron #5 | PDB | -0.57 | 1.8e-08 | +0.49 | 2.8e-08 | 7 | supported | Structure ↗ |
| HGFR | HGFR PTKc_MET_Ron | PDB | +0.32 | 3.6e-04 | -0.36 | 3.6e-05 | 7 | supported | Structure ↗ |
| HGFR | HGFR PTKc_MET_Ron #4 | PDB | -0.30 | 1.3e-04 | +0.20 | 5.9e-04 | 9 | supported | Structure ↗ |
| HGFR | HGF res 1306-1357 | AF-M | +0.36 | 0.207 | +0.24 | 8.5e-04 | 4 | supported | Structure ↗ |
| MRAS | PIK3CA | PDB | -1.39 | 2.8e-47 | +0.58 | 3.3e-13 | 10 | supported | Structure ↗ |
| MRAS | RALGDS | AF-M | -0.81 | 4.3e-39 | +0.58 | 6.1e-15 | 21 | supported | Structure ↗ |
| MRAS | RAPGEF2 | AF-M | -0.91 | 4.3e-39 | +0.64 | 1.2e-18 | 21 | supported | Structure ↗ |
| MRAS | MRAS | PDB | -0.96 | 6.6e-39 | +0.54 | 6.4e-15 | 17 | supported | Structure ↗ |
| MRAS | RAPGEF5 | AF-M | -0.82 | 3.3e-27 | +0.89 | 7.3e-28 | 15 | supported | Structure ↗ |
| MRAS | CRAF | AF-M | -0.98 | 1.8e-24 | +0.46 | 3.2e-08 | 10 | supported | Structure ↗ |
| MRAS | BRAF | AF-M | -0.94 | 3.7e-22 | +0.37 | 1.7e-06 | 9 | supported | Structure ↗ |
| MRAS | RAPGEF6 | AF-M | -0.53 | 3.6e-21 | +0.63 | 1.1e-13 | 14 | supported | Structure ↗ |
| MRAS | LZTR1 | PDB | -0.52 | 5.1e-16 | +0.63 | 8.2e-12 | 15 | supported | Structure ↗ |
| MRAS | SHOC2 | PDB | -0.51 | 8.1e-04 | +1.43 | 6.1e-13 | 3 | supported | Structure ↗ |
| MRAS | PPP1CA | PDB | -0.47 | 4.2e-07 | +0.19 | 0.006 | 10 | supported | Structure ↗ |
| MRAS | PPP1CC | PDB | -0.37 | 6.8e-05 | +0.12 | 0.088 | 9 | supported | Structure ↗ |
| SHP2 | GAB2 SH2_C-SH2_SHP_like #2 | AF-M | -0.38 | 2.1e-42 | -0.02 | 0.444 | 26 | supported | Structure ↗ |
| SHP2 | GAB1 | AF-M | -0.48 | 3.4e-42 | -0.10 | 0.079 | 18 | supported | Structure ↗ |
| SHP2 | GAB3 SH2_N-SH2_SHP_like | AF-M | -0.39 | 2.1e-40 | -0.05 | 0.255 | 25 | supported | Structure ↗ |
| SHP2 | GAB1 | PDB | -0.65 | 2.4e-27 | -0.13 | 0.456 | 9 | supported | Structure ↗ |
| SHP2 | GAB2 SH2_C-SH2_SHP_like | AF-M | -0.54 | 1.3e-26 | -0.01 | 0.523 | 14 | supported | Structure ↗ |
| SHP2 | SOS1 | AF-M | -0.45 | 5.2e-22 | +0.15 | 0.058 | 12 | supported | Structure ↗ |
| SHP2 | GAB3 | RF2-PPI | -0.48 | 7.3e-22 | -0.02 | 0.794 | 13 | supported | Structure ↗ |
| SHP2 | GAB3 SH2_C-SH2_SHP_like | AF-M | -0.63 | 3.6e-21 | -0.12 | 0.209 | 8 | supported | Structure ↗ |
| SHP2 | FRS2 | AF-M | -0.46 | 2.3e-20 | -0.03 | 0.606 | 12 | supported | Structure ↗ |
| SHP2 | THEMIS | AF-M | -0.27 | 1.7e-15 | -0.16 | 0.028 | 10 | supported | Structure ↗ |
| SHP2 | PDCD1 | PDB | -0.45 | 2.7e-15 | -0.09 | 0.917 | 7 | supported | Structure ↗ |
| SHP2 | CD28 | PDB | -0.86 | 1.2e-13 | -0.19 | 0.121 | 3 | supported | Structure ↗ |
| SHP2 | SOS1 | RF2-PPI | -0.26 | 2.2e-13 | +0.24 | 9.8e-04 | 11 | supported | Structure ↗ |
| SHP2 | GRB2 | AF-M | -0.24 | 8.0e-10 | +0.10 | 0.278 | 15 | supported | Structure ↗ |
| SHP2 | SOS2 | RF2-PPI | -0.18 | 2.0e-09 | +0.21 | 0.009 | 10 | supported | Structure ↗ |
| SHP2 | TXNIP | PDB | -0.38 | 9.1e-06 | -0.01 | 0.839 | 8 | supported | Structure ↗ |
| SHP2 | IRS1 | PDB | +0.11 | 1.3e-05 | -0.36 | 4.9e-04 | 5 | supported | Structure ↗ |
| SHP2 | IL6ST | RF2-PPI | +1.90 | 0.009 | -0.69 | 2.9e-04 | 3 | supported | Structure ↗ |
| SHP2 | SHP2 SH2_C-SH2_SHP_like | PDB | -0.06 | 0.199 | -0.29 | 7.6e-04 | 8 | supported | Structure ↗ |
| SHP2 | HDGF | RF2-PPI | +2.02 | 0.874 | -0.81 | 9.5e-04 | 3 | supported | Structure ↗ |
| SHP2 | SHP2 PTPc-N11 | PDB | -0.18 | 0.061 | -0.64 | 0.055 | 3 | supported | Structure ↗ |
| SHP2 | MPZL1 | AF-M | +0.04 | 1.5e-18 | +0.04 | 0.887 | 28 | not supported | Structure ↗ |
| SHP2 | MPZL1 | PDB | +0.16 | 3.0e-06 | -0.08 | 0.301 | 27 | not supported | Structure ↗ |
| SHP2 | cagA | PDB | -0.05 | 5.9e-05 | +0.06 | 0.438 | 5 | not supported | Structure ↗ |
| SHP2 | SHP2 PTPc-N11 #2 | PDB | +0.12 | 0.387 | +0.09 | 0.402 | 4 | not supported | Structure ↗ |
| SHP2 | FN1 | PDB | +0.22 | 0.952 | +0.05 | 0.469 | 3 | not supported | Structure ↗ |
| CRAF | KSR2 | AF-M | -1.21 | 5.9e-62 | +0.01 | 0.411 | 12 | supported | Structure ↗ |
| CRAF | CLEC16A | AF-M | -1.44 | 4.2e-54 | -0.12 | 0.005 | 8 | supported | Structure ↗ |
| CRAF | RAP1B | AF-M | -0.91 | 1.1e-43 | +0.33 | 1.3e-04 | 13 | supported | Structure ↗ |
| CRAF | KSR1 | AF-M | -0.81 | 3.9e-43 | +0.06 | 0.171 | 13 | supported | Structure ↗ |
| CRAF | ARAF | AF-M | -0.94 | 1.3e-39 | +0.04 | 0.342 | 14 | supported | Structure ↗ |
| CRAF | CDC37 | PDB | -1.00 | 1.0e-33 | -1.07 | 1.8e-34 | 12 | supported | Structure ↗ |
| CRAF | BRAF | AF-M | -0.95 | 1.3e-33 | -0.26 | 5.1e-04 | 11 | supported | Structure ↗ |
| CRAF | STK3 STKc_C-Raf #2 | AF-M | -2.04 | 6.6e-32 | +0.11 | 0.963 | 3 | supported | Structure ↗ |
| CRAF | GNB1 | RF2-PPI | -0.75 | 5.1e-28 | +0.20 | 0.003 | 11 | supported | Structure ↗ |
| CRAF | RAP1A | PDB | -1.21 | 1.8e-26 | +0.11 | 0.252 | 7 | supported | Structure ↗ |
| CRAF | GNB2 | AF-M | -1.06 | 7.5e-25 | -0.16 | 0.016 | 6 | supported | Structure ↗ |
| CRAF | KRAS | PDB | -1.16 | 1.1e-24 | +0.09 | 0.138 | 7 | supported | Structure ↗ |
| CRAF | NRAS | AF-M | -0.54 | 8.5e-23 | +0.25 | 1.6e-05 | 14 | supported | Structure ↗ |
| CRAF | KRAS | AF-M | -0.53 | 1.1e-22 | +0.24 | 3.1e-05 | 14 | supported | Structure ↗ |
| CRAF | RAP1A | AF-M | -0.60 | 2.2e-22 | +0.31 | 2.0e-04 | 10 | supported | Structure ↗ |
| CRAF | PPP1CB | RF2-PPI | +1.91 | 2.7e-22 | -0.50 | 4.2e-07 | 7 | supported | Structure ↗ |
| CRAF | HRAS | PDB | -1.14 | 5.3e-22 | +0.15 | 0.015 | 6 | supported | Structure ↗ |
| CRAF | MRAS | AF-M | -0.62 | 3.9e-21 | +0.21 | 2.1e-04 | 10 | supported | Structure ↗ |
| CRAF | RRAS2 | AF-M | -0.53 | 1.1e-20 | +0.22 | 1.5e-04 | 13 | supported | Structure ↗ |
| CRAF | HRAS | AF-M | -0.53 | 1.1e-19 | +0.25 | 1.3e-04 | 14 | supported | Structure ↗ |
| CRAF | YWHAB res 142-611 | AF-M | +2.00 | 5.5e-18 | -0.42 | 9.0e-05 | 7 | supported | Structure ↗ |
| CRAF | YWHAB STKc_C-Raf | AF-M | +1.02 | 0.075 | -0.67 | 5.6e-17 | 10 | supported | Structure ↗ |
| CRAF | RAP2A | AF-M | -0.58 | 5.7e-15 | +0.37 | 1.8e-05 | 8 | supported | Structure ↗ |
| CRAF | SFN C1_A_C-Raf | AF-M | +1.62 | 4.4e-12 | -0.49 | 3.0e-08 | 9 | supported | Structure ↗ |
| CRAF | HSP90AB1 | PDB | -0.02 | 0.002 | -0.55 | 6.8e-10 | 6 | supported | Structure ↗ |
| CRAF | NDUFA10 res 94-522 | AF-M | +0.34 | 3.2e-07 | +0.35 | 1.1e-09 | 21 | supported | Structure ↗ |
| CRAF | TAOK1 | AF-M | -0.42 | 3.3e-09 | -0.14 | 0.009 | 9 | supported | Structure ↗ |
| CRAF | MAP2K6 | AF-M | -0.37 | 5.0e-09 | -0.30 | 1.7e-06 | 9 | supported | Structure ↗ |
| CRAF | GNB2 | RF2-PPI | -0.47 | 1.5e-08 | +0.22 | 0.011 | 9 | supported | Structure ↗ |
| CRAF | MAP2K3 | AF-M | -0.34 | 4.3e-08 | -0.31 | 2.2e-06 | 9 | supported | Structure ↗ |
| CRAF | NR3C1 C1_A_C-Raf | AF-M | -0.59 | 6.6e-08 | -0.01 | 0.482 | 5 | supported | Structure ↗ |
| CRAF | MAP3K1 | AF-M | -0.34 | 1.5e-07 | -0.20 | 0.006 | 7 | supported | Structure ↗ |
| CRAF | MEK1 | PDB | -0.08 | 1.2e-04 | -0.27 | 8.4e-07 | 18 | supported | Structure ↗ |
| CRAF | MEK1 | RF2-PPI | -0.33 | 2.7e-06 | -0.25 | 1.4e-04 | 9 | supported | Structure ↗ |
| CRAF | MAP2K5 | AF-M | -0.29 | 5.1e-06 | -0.26 | 8.0e-06 | 10 | supported | Structure ↗ |
| CRAF | A0A1B0GUL7 | RF2-PPI | -0.28 | 2.3e-04 | -0.27 | 2.1e-04 | 7 | supported | Structure ↗ |
| CRAF | CSNK1G1 | AF-M | +0.89 | 7.4e-04 | -0.25 | 7.0e-04 | 10 | supported | Structure ↗ |
| CRAF | JAK2 | AF-M | -0.23 | 7.1e-04 | -0.03 | 0.503 | 13 | supported | Structure ↗ |
| CRAF | MEK1 | AF-M | -0.20 | 0.001 | -0.05 | 0.127 | 13 | supported | Structure ↗ |
| CRAF | NR3C1 STKc_C-Raf | AF-M | +0.09 | 0.686 | -0.27 | 0.002 | 6 | supported | Structure ↗ |
| CRAF | SFN res 612-622 | AF-M | -0.25 | 0.047 | -0.30 | 0.003 | 4 | supported | Structure ↗ |
| CRAF | STK3 STKc_C-Raf | AF-M | -0.28 | 0.007 | -0.25 | 0.005 | 4 | supported | Structure ↗ |
| CRAF | LSM14A | AF-M | +0.48 | 0.027 | -0.24 | 0.055 | 4 | supported | Structure ↗ |
| CRAF | LOC113496266 | PDB | -0.22 | 0.046 | -0.03 | 0.827 | 6 | supported | Structure ↗ |
| CRAF | MEK2 | RF2-PPI | -0.05 | 0.298 | -0.16 | 0.001 | 18 | not supported | Structure ↗ |
| CRAF | MEK2 | AF-M | -0.11 | 0.009 | -0.13 | 0.013 | 16 | not supported | Structure ↗ |
| CRAF | NDUFA10 C1_A_C-Raf | AF-M | +0.45 | 0.055 | +0.13 | 0.351 | 5 | not supported | Structure ↗ |
| RET | RET | PDB | -0.20 | 1.3e-28 | +0.46 | 1.7e-19 | 20 | supported | Structure ↗ |
| RET | RAPH1 | RF2-PPI | +0.21 | 3.1e-21 | -0.12 | 0.468 | 6 | supported | Structure ↗ |
| RET | SORL1 PTKc_RET #2 | RF2-PPI | -0.25 | 3.2e-16 | +0.04 | 0.609 | 7 | supported | Structure ↗ |
| RET | PLCG1 | AF-M | +0.19 | 4.1e-12 | -0.55 | 8.7e-13 | 8 | supported | Structure ↗ |
| RET | PTPRA | RF2-PPI | -0.20 | 1.3e-07 | +0.35 | 0.005 | 5 | supported | Structure ↗ |
| RET | SORL1 PTKc_RET | RF2-PPI | -0.22 | 9.8e-07 | -0.19 | 0.095 | 8 | supported | Structure ↗ |
| RET | NTRK1 | AF-M | -0.14 | 0.730 | -0.29 | 0.019 | 3 | supported | Structure ↗ |
| RET | GNPTAB | RF2-PPI | +0.13 | 2.1e-22 | -0.11 | 0.319 | 8 | not supported | Structure ↗ |
| RET | CBLC | RF2-PPI | +0.17 | 5.6e-15 | -0.12 | 0.207 | 4 | not supported | Structure ↗ |
| RET | GFRA1 | AF-M | -0.14 | 0.173 | -0.17 | 0.258 | 4 | not supported | Structure ↗ |
| SOS1 | HRAS | AF-M | -1.70 | 8.1e-97 | +0.80 | 1.1e-36 | 15 | supported | Structure ↗ |
| SOS1 | NRAS RasGEF | AF-M | -1.71 | 8.1e-96 | +0.77 | 2.2e-35 | 14 | supported | Structure ↗ |
| SOS1 | KRAS RasGEF | AF-M | -1.69 | 4.0e-95 | +0.78 | 1.2e-35 | 14 | supported | Structure ↗ |
| SOS1 | RAP1A | RF2-PPI | -1.60 | 1.9e-92 | +0.72 | 1.4e-31 | 14 | supported | Structure ↗ |
| SOS1 | HRAS RasGEF | PDB | -1.49 | 2.2e-89 | +0.72 | 5.4e-31 | 14 | supported | Structure ↗ |
| SOS1 | KRAS | PDB | -1.50 | 1.7e-86 | +0.69 | 3.6e-29 | 14 | supported | Structure ↗ |
| SOS1 | RIT2 RasGEF | AF-M | -1.67 | 8.5e-84 | +0.67 | 8.7e-26 | 13 | supported | Structure ↗ |
| SOS1 | RIT1 RasGEF | AF-M | -1.64 | 2.8e-83 | +0.69 | 4.6e-27 | 13 | supported | Structure ↗ |
| SOS1 | RASL11A | RF2-PPI | -1.71 | 2.5e-70 | +0.87 | 1.5e-28 | 9 | supported | Structure ↗ |
| SOS1 | ITSN1 RasGEF #2 | RF2-PPI | -1.55 | 1.4e-63 | +0.75 | 2.5e-23 | 9 | supported | Structure ↗ |
| SOS1 | RAC1 RasGEF | AF-M | -1.65 | 3.7e-60 | +0.92 | 7.4e-29 | 9 | supported | Structure ↗ |
| SOS1 | RASL11B | RF2-PPI | -1.45 | 1.2e-54 | +0.73 | 1.3e-20 | 9 | supported | Structure ↗ |
| SOS1 | RERGL | RF2-PPI | -1.93 | 3.2e-51 | +1.30 | 8.6e-29 | 5 | supported | Structure ↗ |
| SOS1 | FOXO1 | RF2-PPI | -1.59 | 6.0e-50 | +0.69 | 1.2e-16 | 7 | supported | Structure ↗ |
| SOS1 | NCK2 | RF2-PPI | -1.53 | 3.1e-49 | +0.57 | 5.8e-13 | 7 | supported | Structure ↗ |
| SOS1 | RERG | RF2-PPI | -1.38 | 9.5e-47 | +0.88 | 1.4e-24 | 8 | supported | Structure ↗ |
| SOS1 | C3orf18 | RF2-PPI | -1.47 | 7.7e-46 | +0.71 | 2.4e-16 | 7 | supported | Structure ↗ |
| SOS1 | ATRX | RF2-PPI | -1.22 | 9.4e-35 | +0.76 | 8.2e-17 | 8 | supported | Structure ↗ |
| SOS1 | ARHGAP39 | RF2-PPI | -1.97 | 2.2e-31 | +1.29 | 1.9e-18 | 3 | supported | Structure ↗ |
| SOS1 | BLNK | RF2-PPI | -0.95 | 4.5e-24 | +0.33 | 2.5e-07 | 9 | supported | Structure ↗ |
| SOS1 | RAC1 RasGEF #2 | AF-M | -1.42 | 1.4e-18 | +0.80 | 1.7e-07 | 3 | supported | Structure ↗ |
| SOS1 | KRAS RasGEF+RasGEFN | AF-M | -0.65 | 2.8e-18 | +0.59 | 4.6e-14 | 9 | supported | Structure ↗ |
| SOS1 | NRAS RasGEF+RasGEFN | AF-M | -0.33 | 1.4e-14 | +0.56 | 2.1e-13 | 11 | supported | Structure ↗ |
| SOS1 | RIT2 RasGEFN | AF-M | -0.20 | 4.9e-08 | +0.41 | 4.1e-10 | 13 | supported | Structure ↗ |
| SOS1 | RIT1 RasGEFN | AF-M | -0.33 | 2.4e-07 | +0.44 | 1.5e-09 | 10 | supported | Structure ↗ |
| SOS1 | HRAS RasGEFN | PDB | +0.02 | 7.0e-05 | +0.39 | 4.7e-09 | 16 | supported | Structure ↗ |
| SOS1 | EGFR | RF2-PPI | -0.58 | 1.8e-07 | +0.28 | 0.045 | 8 | supported | Structure ↗ |
| SOS1 | SHP2 | AF-M | +1.24 | 2.6e-06 | -0.25 | 0.020 | 4 | supported | Structure ↗ |
| SOS1 | PTPN6 | AF-M | +1.23 | 2.6e-06 | -0.25 | 0.020 | 4 | supported | Structure ↗ |
| SOS1 | SOS2 | RF2-PPI | -0.12 | 0.905 | +0.14 | 0.051 | 5 | not supported | Structure ↗ |
| SOS1 | ITSN1 RasGEF | RF2-PPI | +0.02 | 0.100 | +0.07 | 0.802 | 6 | not supported | Structure ↗ |
| SOS2 | RAP1B | AF-M | -1.80 | 4.8e-114 | +1.12 | 2.4e-46 | 20 | supported | Structure ↗ |
| SOS2 | ZNF410 | RF2-PPI | -1.67 | 1.7e-65 | +1.12 | 1.0e-25 | 10 | supported | Structure ↗ |
| SOS2 | NCK2 | RF2-PPI | -1.65 | 7.0e-61 | +1.05 | 5.0e-26 | 11 | supported | Structure ↗ |
| SOS2 | FOXO1 | RF2-PPI | -1.42 | 1.7e-51 | +0.94 | 1.1e-21 | 12 | supported | Structure ↗ |
| SOS2 | RASL11A | RF2-PPI | -1.48 | 3.2e-51 | +0.95 | 1.4e-21 | 11 | supported | Structure ↗ |
| SOS2 | BIN1 | RF2-PPI | -2.15 | 2.3e-37 | +1.40 | 2.0e-18 | 4 | supported | Structure ↗ |
| SOS2 | RASL11B | RF2-PPI | -1.31 | 4.9e-37 | +0.84 | 8.7e-17 | 10 | supported | Structure ↗ |
| SOS2 | EGFR | RF2-PPI | -1.17 | 2.2e-26 | +0.96 | 4.2e-14 | 7 | supported | Structure ↗ |
| SOS2 | RERG | RF2-PPI | -1.39 | 3.8e-24 | +0.75 | 6.1e-08 | 6 | supported | Structure ↗ |
| SOS2 | CD2AP | RF2-PPI | -1.10 | 4.1e-21 | +0.61 | 1.2e-08 | 8 | supported | Structure ↗ |
| SOS2 | SHC1 | RF2-PPI | -0.95 | 2.5e-17 | +0.64 | 1.2e-06 | 7 | supported | Structure ↗ |
| SOS2 | ABI1 | RF2-PPI | -0.96 | 3.7e-11 | +0.49 | 0.001 | 3 | supported | Structure ↗ |
| SOS2 | STARD13 | RF2-PPI | -0.93 | 8.7e-10 | +0.45 | 0.002 | 5 | supported | Structure ↗ |
| SOS2 | SOS1 | RF2-PPI | +0.01 | 0.135 | -0.17 | 0.229 | 4 | not supported | Structure ↗ |
| SOS2 | ARHGAP39 | RF2-PPI | -0.33 | 0.150 | +0.15 | 0.478 | 5 | not supported | Structure ↗ |