Proteins / SHP2 / interface with SHP2

SHP2 – SHP2

PDB PDB 5EHR (chains A/B) · PTPc-N11 supported · 1 of 3 complexes SHP2 volcano ↗

Colour SHP2 (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 3 interface and 166 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 5EHR · X-ray, 1.70 Å · chains A/B
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099
Primary citation: Chen et al., Nature 535 (2016)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 5EHR (chains A/B) · chain B (shown) · not supported
PDB 7RCT (chains A/B) · chain A
PDB 8T6G (chains B/A) · chain A · not supported

Residue

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