Proteins / SHP2 / interface with PDCD1

SHP2 – PDCD1

PDB PDB 6ROZ (chains A/B) supported · 1 of 1 complexes SHP2 volcano ↗

Colour SHP2 (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 7 interface and 38 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 6ROZ · X-ray, 2.89 Å · chains A/B
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif
Primary citation: Marasco et al., Sci Adv 6 (2020)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 6ROZ (chains A/B) (shown)

Residue

Click a residue in the viewer.