Proteins / BRAF / interface with HSP90AB1

BRAF – HSP90AB1

PDB PDB 7ZR0 (chains K/A) not supported · 0 of 2 complexes BRAF volcano ↗

Colour BRAF (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 4 interface and 93 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 7ZR0 · electron microscopy, 3.40 Å · chains K/A
CryoEM structure of HSP90-CDC37-BRAF(V600E) complex.
Primary citation: Oberoi et al., Nat Commun 13 (2022)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 7ZR0 (chains K/A) (shown) · not supported
PDB 7ZR5 (chains K/A) · not supported

Residue

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