Proteins / GRB2 / interface with GRB2

GRB2 – GRB2

PDB PDB 2HUW (chains A/B) · SH2_GRB2_like supported · 4 of 4 complexes GRB2 volcano ↗

Colour GRB2 (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 15 interface and 26 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 2HUW · X-ray, 1.90 Å · chains A/B
X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
Primary citation: Benfield et al., Angew Chem Int Ed Engl 45 (2006)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 2HUW (chains A/B) · chain A (shown)
PDB 2HUW (chains A/B) · chain B
PDB 6WM1 (chains A/C) · chain A
PDB 6WM1 (chains A/C) · chain B

Residue

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