Proteins / SHP2 / interface with SHP2

SHP2 – SHP2

PDB PDB 8B5Y (chains A/B) · SH2_C-SH2_SHP_like supported · 4 of 4 complexes SHP2 volcano ↗

Colour SHP2 (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 8 interface and 174 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 8B5Y · X-ray, 1.83 Å · chains A/B
SHP2 in complex with allosteric imidazopyrazine inhibitor
Primary citation: Torrente et al., ACS Med Chem Lett 14 (2023)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 8B5Y (chains A/B) · chain A (shown)
PDB 6CMP (chains B/A) · chain A
PDB 6CMP (chains B/A) · chain B
PDB 8B5Y (chains A/B) · chain B

Residue

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