Proteins / MEK1 / interface with 14-3-3zeta

MEK1 – 14-3-3zeta

PDB PDB 9MMR (chains B/C) not supported · 0 of 1 complexes MEK1 volcano ↗

Colour MEK1 (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 4 interface and 121 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 9MMR · electron microscopy, 3.90 Å · chains B/C
Cryo-EM structure of CRAF/MEK1/14-3-3 complex (open monomer conformation, CRAF Y340D/Y341D mutant)
Primary citation: Jang et al., Nat Commun 16 (2025)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 9MMR (chains B/C) (shown) · not supported

Residue

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