Proteins / MEK1 / interface with CRAF

MEK1 – CRAF

PDB PDB 9MMQ (chains A/B) not supported · 0 of 3 complexes MEK1 volcano ↗

Colour MEK1 (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 15 interface and 96 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 9MMQ · electron microscopy, 2.90 Å · chains A/B
Cryo-EM structure of CRAF/MEK1 complex (kinase domain)
Primary citation: Jang et al., Nat Commun 16 (2025)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 9MMQ (chains A/B) (shown) · not supported
PDB 9MMR (chains A/B) · not supported
PDB 9MMS (chains A/B) · not supported

Residue

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