Proteins / MEK1 / interface with MEK1

MEK1 – MEK1

PDB PDB 7B7R (chains A/B) · PKc_MAP2K1 supported · 1 of 6 complexes MEK1 volcano ↗

Colour MEK1 (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 14 interface and 84 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 7B7R · X-ray, 1.70 Å · chains A/B
MEK1 in complex with compound 4
Primary citation: Di Fruscia et al., ACS Med Chem Lett 12 (2021)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 7B7R (chains A/B) · chain B (shown) · not supported
PDB 7B7R (chains A/B) · chain A · not supported
PDB 7B94 (chains A/B) · chain A · not supported
PDB 7B94 (chains A/B) · chain B · not supported
PDB 7B9L (chains A/B) · chain A · not supported
PDB 7B9L (chains A/B) · chain B

Residue

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