Proteins / SOS1 / interface with KRAS

SOS1 – KRAS

PDB PDB 6EPM (chains R/S) supported · 5 of 5 complexes SOS1 volcano ↗

Colour SOS1 (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 14 interface and 96 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 6EPM · X-ray, 2.50 Å · chains R/S
Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F1
Primary citation: Hillig et al., Proc Natl Acad Sci U S A 116 (2019)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 6EPM (chains R/S) (shown)
PDB 6EPN (chains R/S)
PDB 6EPO (chains R/S)
PDB 6EPP (chains R/S)
PDB 8BE4 (chains R/S)

Residue

Click a residue in the viewer.