Proteins / CRAF / interface with KRAS

CRAF – KRAS

PDB PDB 8T74 (chains A/B) supported · 5 of 5 complexes CRAF volcano ↗

Colour CRAF (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 7 interface and 23 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 8T74 · X-ray, 1.65 Å · chains A/B
Crystal structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD)
Primary citation: Whitley et al., Sci Adv 10 (2024)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 8T74 (chains A/B) (shown)
PDB 6VJJ (chains A/B)
PDB 6XI7 (chains A/B)
PDB 8EPW (chains A/B)
PDB 9YGS (chains A/B)

Residue

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