Proteins / SHP2 / interface with GAB1

SHP2 – GAB1

PDB PDB 9EIK (chains A/B) supported · 4 of 4 complexes SHP2 volcano ↗

Colour SHP2 (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 10 interface and 32 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 9EIK · X-ray, 1.25 Å · chains A/B
Crystal structure of N-SH2 domain of SHP2 with T42A mutation bound to GAB1 tyrosine phosphorylated peptide (624-633) QVEpYLDLDLD
Primary citation: Glaser et al., Proc Natl Acad Sci U S A 123 (2026)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 9EIK (chains A/B) (shown)
PDB 4QSY (chains A/B)
PDB 9EHD (chains A/B)
PDB 9QA5 (chains A/B)

Residue

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