Proteins / KRAS / interface with PPIA

KRAS – PPIA

PDB PDB 8TBK (chains A/D) supported · 4 of 4 complexes KRAS volcano ↗

Colour KRAS (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 4 interface and 63 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 8TBK · X-ray, 1.26 Å · chains A/D
Tricomplex of RMC-7977, KRAS G12C, and CypA
Primary citation: Holderfield et al., Nature 629 (2024)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 8TBK (chains A/D) (shown)
PDB 8G9P (chains A/D)
PDB 8G9Q (chains A/D)
PDB 8TBN (chains B/C)

Residue

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