Proteins / BRAF / interface with BRAF

BRAF – BRAF

PDB PDB 4MNE (chains B/C) · STKc_Raf supported · 8 of 8 complexes BRAF volcano ↗

Colour BRAF (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 9 interface and 99 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 4MNE · X-ray, 2.85 Å · chains B/C
Crystal structure of the BRAF:MEK1 complex
Primary citation: Haling et al., Cancer Cell 26 (2014)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 4MNE (chains B/C) · chain B (shown)
PDB 4MNE (chains B/C) · chain A
PDB 5ITA (chains B/A) · chain A
PDB 5ITA (chains B/A) · chain B
PDB 8C7X (chains B/A) · chain A
PDB 8C7X (chains B/A) · chain B
PDB 8C7Y (chains A/B) · chain A
PDB 8C7Y (chains A/B) · chain B

Residue

Click a residue in the viewer.