MAPK variant effect atlas

Proteins Interactions

Proteins / SHP2 / interface with IL6ST

SHP2 – IL6ST

RF2-PPI RF2-PPI AF supported · 1 of 1 complexes SHP2 volcano ↗

Colour SHP2 (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 3 interface and 206 control positions in the structure shown.

Structure shown: source

Predicted model from the human-proteome RoseTTAFold2-PPI screen of Zhang et al., Science 390, eadt1630 (2025); data Dryad (CC0) · high confidence.

Complexes merged into this interface

RF2-PPI AF (shown)

Residue

Click a residue in the viewer.

Created by Sriram Pendyala with help from Claude Opus (Anthropic), based on the paper by Jessica J. Simon*, Sriram Pendyala*, …, Dustin J. Maly, Douglas M. Fowler (*equal contribution; preprint coming soon).

Code: GitHub (FowlerLab/MAPK-LABEL-seq) · Data: Zenodo (doi:10.5281/zenodo.23121367). Structures: RCSB PDB, Predictomes (AlphaFold-Multimer), Zhang et al. 2025 (RoseTTAFold2-PPI).