Proteins / BRAF / interface with CDC37

BRAF – CDC37

PDB PDB 7ZR0 (chains K/C) supported · 3 of 3 complexes BRAF volcano ↗

Colour BRAF (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 11 interface and 84 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 7ZR0 · electron microscopy, 3.40 Å · chains K/C
CryoEM structure of HSP90-CDC37-BRAF(V600E) complex.
Primary citation: Oberoi et al., Nat Commun 13 (2022)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 7ZR0 (chains K/C) (shown)
PDB 7ZR5 (chains K/C)
PDB 7ZR6 (chains K/C)

Residue

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