Proteins / SHP2 / interface with MPZL1

SHP2 – MPZL1

PDB PDB 9MQ5 (chains A/B) not supported · 0 of 1 complexes SHP2 volcano ↗

Colour SHP2 (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 27 interface and 42 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 9MQ5 · X-ray, 1.70 Å · chains A/B
Crystal structure SHP2 tandem SH2 domains in complex with PZR doubly tyrosine phosphorylated ITIM peptide
Primary citation: Perla et al., Proc Natl Acad Sci U S A 122 (2025)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 9MQ5 (chains A/B) (shown) · not supported

Residue

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