Proteins / KSR2 / interface with MEK1

KSR2 – MEK1

PDB PDB 7JUR (chains C/B) supported · 5 of 5 complexes KSR2 volcano ↗

Colour KSR2 (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 19 interface and 99 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 7JUR · X-ray, 2.82 Å · chains C/B
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib
Primary citation: Khan et al., Nature 588 (2020)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 7JUR (chains C/B) (shown)
PDB 7JUQ (chains C/B)
PDB 7JUS (chains C/B)
PDB 7JUT (chains C/B)
PDB 7JUU (chains C/B)

Residue

Click a residue in the viewer.