Proteins / CRAF / interface with CDC37

CRAF – CDC37

PDB PDB 8GAE (chains D/C) supported · 4 of 4 complexes CRAF volcano ↗

Colour CRAF (chain A) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 11 interface and 86 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 8GAE · electron microscopy, 3.30 Å · chains D/C
Hsp90 provides platform for CRaf dephosphorylation by PP5
Primary citation: Jaime-Garza et al., Nat Commun 14 (2023)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 8GAE (chains D/C) (shown)
PDB 7Z38 (chains C/D)
PDB 8GFT (chains D/C)
PDB 8U1L (chains C/D)

Residue

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