Proteins / RET / interface with RET

RET – RET

PDB PDB 6NEC (chains C/A) supported · 10 of 10 complexes RET volcano ↗

Colour RET (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 21 interface and 93 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 6NEC · X-ray, 1.87 Å · chains C/A
STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB
Primary citation: Terzyan et al., J Biol Chem 294 (2019)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 6NEC (chains C/A) · chain B (shown)
PDB 2IVS (chains B/A) · chain A
PDB 2IVS (chains B/A) · chain B
PDB 6I82 (chains A/B) · chain A
PDB 6I82 (chains A/B) · chain B
PDB 6NEC (chains C/A) · chain A
PDB 7DUA (chains B/A) · chain A
PDB 7DUA (chains B/A) · chain B
PDB 7JU5 (chains A/B) · chain A
PDB 7JU5 (chains A/B) · chain B

Residue

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