Proteins / EGFR / interface with EGFR

EGFR – EGFR

PDB PDB 6TFV (chains B/A) · PTKc_EGFR supported · 1 of 6 complexes EGFR volcano ↗

Colour EGFR (chain B) by

Interface statistics (basal)

Merged point of Fig. 6c,d: median Cohen's d of the complexes below; q is the BH-FDR of their geometric-mean p. A complex is supported at q < 0.05 and |d| ≥ 0.2. 11 interface and 91 control positions in the structure shown.

Structure shown: source

Experimental structure PDB 6TFV · X-ray, 1.50 Å · chains B/A
Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 18b
Primary citation: Lategahn et al., J Med Chem 63 (2020)
RCSB Protein Data Bank (Berman et al., Nucleic Acids Res. 2000); the two chains were extracted and renumbered to UniProt (SIFTS) for this analysis.

Complexes merged into this interface

PDB 6TFV (chains B/A) · chain B (shown) · not supported
PDB 6TFV (chains B/A) · chain A · not supported
PDB 6TG0 (chains B/A) · chain A · not supported
PDB 6TG0 (chains B/A) · chain B
PDB 6TG1 (chains B/A) · chain A · not supported
PDB 6TG1 (chains B/A) · chain B · not supported

Residue

Click a residue in the viewer.